Relationships between Biotin and Vitamin B12

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Abstract
Interrelationships between biotin and vitamin B12 were studied. Data indicate that vitamin B12 administration to rats receiving a biotin-free diet exerts a favorable effect on the growth rate and on the delay of the deficiency symptoms in these experimental conditions. Vitamin B12 appears also to have an effect on transcarbamylase activities analogous to biotin, possibly due to an increased intestinal synthesis of biotin and tissue storage. In addition, biotin administration influences methylation examined in the rat in vivo (urinary elimination of N-methylnicotinamide) and in vitro (betainehomocysteine transmethylase) as does vitamin B12 although to a lesser extent. The significance of the interrelationship between vitamins is discussed.

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