Specificity of the Carcinoembryonic Antigen (CEA)

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Abstract
Beginning in 1965, a series of elegant studies by Gold and his colleagues have been carried out involving the detection and characterization of a new, apparently specific, surface antigen associated with adenocarcinoma of the human colon. This particular tumor was chosen for study because of its highly localized nature; thus, both control and tumor tissue could be obtained from the same patients, thereby eliminating isoantigenic complications in the search for a "tumor-specific" antigen.1 Heterologous immune rabbit serums were made specific for tumor antigens both by adsorption with control colon tissue and by immunization of rabbits previously made tolerant to control . . .