4-hydroxyaminoquinoline-1-oxide-induced ultrastructural changes in the guinea-pig exocrine pancreas

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Abstract
4-Hydroxyaminoquinoline, a carcinogen, was injected i.v. into guinea pigs in a single dose of 22.5 mg/kg. The sequential morphological changes in the exocrine cells of the pancreas were studied by EM at selected intervals of 18-60 h. The earliest alterations in the acinar cells comprised nucleolar segregation into granular and fibrillar components and minimal dilatation of endoplasmic reticulum. At later intervals all cytoplasmic organelles appeared altered. The endoplasmic reticular channels were markedly dilated with depletion of membrane bound and free ribosomes. The mitochondria were swollen and irregular with disruption of limiting membranes and cristae. Zymogen granules were markedly reduced or completely absent. The hyaloplasm contained morphologically variable cytoplasmic degenerative bodies. Centriacinar and ductal epithelial cells also showed similar changes.