PYODERMA GANGRENOSUM IN ULCERATIVE COLITIS

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Abstract
ULCERONECROTIC lesions of the skin occurring in association with chronic ulcerative colitis have previously been described by Felsen,1Greenbaum,2Jones,3Brunsting4and Cohen5under the terms pyoderma gangrenosum and ecthyma gangrenosum. The following case is reported because such lesions are rare and their causation is still controversial. Felsen described 3 cases in 1941 and reported Escherichia coli, Staphylococcus aureus and nonhemolytic streptococcus in his cases 1, 2 and 3, respectively. He concluded, therefore, that a single bacterial agent is not responsible and expressed the belief that the lesions were probably due to a nutritional disturbance. In reporting 6 cases, Greenbaum also commented on the divergent bacteria observed. His attempts to reproduce lesions by inoculation with a single viable organism failed but were successful when pus was injected into patients in 2 cases and when two organisms were injected simultaneously into patients in 4 cases. He

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