IN VIVO INTERACTIONS BETWEEN THE BENZODIAZEPINE ANTAGONIST Ro 15–1788 AND THE STEROID ANAESTHETIC ALTHESIN IN RATS

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Abstract
Althesin and Δ 16-alphaxalone have been used alone and in combination with the benzodiazepine antagonist Ro 15–1788 to investigate any protective effect these drugs might have against bicuculline- induced convulsions in rats. We found that Althesin provided good protection against bicuculline- induced convulsions which was enhanced when Ro 15–1788 was also present. Δ 16- Alphaxalone lacks the anaesthetic properties of Altbesin, but did have some activity in preventing bicuculline-induced convulsions, although it was less effective than Althesin. Its action was not enhanced by treatment with Ro 15–1788. Although we have no definitive explanation of these results, it is possible that when Ro 15–1788 is used clinically, it may interact with other drugs not related chemically to the benzodiazepines.