Bone morphogenetic protein-3 is a negative regulator of bone density
- 1 January 2001
- journal article
- letter
- Published by Springer Nature in Nature Genetics
- Vol. 27 (1) , 84-88
- https://doi.org/10.1038/83810
Abstract
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-β (TGF-β) superfamily. Many BMPs are produced in bone and show osteogenic activity, suggesting that they may be determinants of bone mass. BMP3 was originally purified from bone as osteogenin, which induces osteogenic differentiation1. Recombinant BMP3 (rhBMP3) has no biological activity, however, leaving its role in skeletal growth unclear. Here we show that BMP3 is an antagonist of osteogenic BMPs: BMP3 dorsalizes Xenopus laevis embryos, inhibits BMP2-mediated induction of Msx2 and blocks BMP2-mediated differentiation of osteoprogenitor cells into osteoblasts. These effects appear to be mediated through activin receptors. Finally, Bmp3−/− mice have twice as much trabecular bone as wild-type littermates, indicating that BMP3, the most abundant BMP in adult bone, is a negative determinant of bone density.Keywords
This publication has 29 references indexed in Scilit:
- Transient Production of Bone Morphogenetic Protein 2 by Allogeneic Transplanted Transduced Cells Induces Bone FormationHuman Gene Therapy, 2000
- Id Genes Are Direct Targets of Bone Morphogenetic Protein Induction in Embryonic Stem CellsJournal of Biological Chemistry, 1999
- Identification of Rat Bone Morphogenetic Protein-3b (BMP-3b), a New Member of BMP-3Biochemical and Biophysical Research Communications, 1996
- Premature suture closure and ectopic cranial bone in mice expressing Msx2 transgenes in the developing skull.Proceedings of the National Academy of Sciences, 1995
- Efficient Expression of a Heterodimer of Bone Morphogenetic Protein Subunits Using a Baculovirus Expression SystemBiochemical and Biophysical Research Communications, 1995
- Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage [published erratum appears in J Cell Biol 1995 Feb;128(4):following 713]The Journal of cell biology, 1994
- The transforming growth factor beta family and induction of the vertebrate mesoderm: bone morphogenetic proteins are ventral inducers.Proceedings of the National Academy of Sciences, 1994
- Characterization and relationship of dpp receptors encoded by the saxophone and thick veins genes in DrosophilaCell, 1994
- Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptorCell, 1994
- Bone Morphogenetic ProteinsPublished by Springer Nature ,1993