Reevaluation of the Dermal Bioavailability of 2,3,7,8-TCDD in Soil

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Abstract
An assessment of risks associated with dioxin-contaminated soil, primarily attributable to Centers for Disease Control (CDC) personnel, has been criticized as too conservative for both residential and industrial locations. In analysis of risks at industrial locations, where the childhood oral ingestion pathway may be neglected, adequate quantification of the dermal exposure pathway is particularly important. Reexamination of the experiment on which CDC assumptions regarding dermal absorption efficiency were based indicates that CDC's dermal risk assessment is not conservative. Results generated using a fugacity-based dermal exposure model incorporated in a physiologically based pharmacokinetic model are presented. Dermal bioavailabilities well in excess of that assumed in the CDC assessment are predicted.