Comparative Clinical Study of Roxithromycin and Josamycin for Suppurative Skin and Soft Tissue Infections by a Double-Blind Method
- 1 January 1989
- journal article
- clinical trial
- Published by The Japanese Association for Infectious Diseases in Kansenshogaku Zasshi
- Vol. 63 (3) , 203-227
- https://doi.org/10.11150/kansenshogakuzasshi1970.63.203
Abstract
The clinical efficacy and safety of Roxithromycin (RU 28965, RU), a new macrolide preparation, were compared with those of Josamycin (JM) in superficial suppurative skin infections.The study was designed as double-blind controlled trial with daily dosages of 300 mg in RU group and 1200 mg in JM group.A total of 209 cases (RU: 105, JM: 104) was analyzed and the final global improvement rating was 82.9% in the RU group and 80.8% in the JM group; there was no significant difference between the two groups.Slight adverse reactions were observed in 3.6%(4 cases) of the RU group and in 4.6%(5 cases) of the JM group.In conclusion, RU at daily doses of 300 mg is as effective as JM at daily doses of 1200 mg in superficial suppurative skin infections.Keywords
This publication has 0 references indexed in Scilit: