Alpha interferon in the treatment of symptomatic myelofibrosis with myeloid metaplasia

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Abstract
2 patients with myelofibrosis and myeloid metaplasia had symptomatic splenomegaly and were treated with interferon alpha‐2c (IFN alpha‐2c). The splenic pain and pressure symptoms disappeared, accompanied by a decrease in the size of the spleen. However, the peripheral blood count worsened and no improvement in the bone marrow fibrosis could be observed.