Sulfamate formation is a major route for detoxification of 2-amino-3-methylimidazo[4, 5-f]quinoline in the rat

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Abstract
The major biliary metabolite of 2-amino-3-methylimidazo-[4, 5-f)quinoline (IQ) in the rat was identified as the sulfamate derivative, N-(3-methylimidazo[4, 5-f]quinolin-2-yl] sulfamic acid. Identification was accomplished primarily by u.v., 1H-n.m.r. and mass spectrometry of the material isolated from bile and confirmed by comparison with material synthesized by reaction of chlorosulfonic add with IQ. The sulfamate was shown to be non-mutagenic in bacterial forward mutation assays. Greater than 20% of an administered dose of IQ could be recovered from feces (17%) and urine (5%) as the sulfamate. Very little unmetabolized IQ was recovered in bile, urine, or feces. Thus, the unusual process of N-sulfation is a major contributor to the detoxification and elimination of IQ in the rat.