HIV Disease and the Endocrine System

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Abstract
HUMAN immunodeficiency virus (HIV) infection and the acquired immunodeficiency syndrome (AIDS) that results from it may involve, directly or indirectly, virtually every organ system. The endocrine system is not spared. Recent reports of endocrine and metabolic abnormalities in patients with HIV infection document the vulnerability of this system in both the early and late stages of the syndrome.1 2 3 4 Potential pathogenetic mechanisms for the endocrinopathies of HIV disease include compromise of endocrine tissue by hemorrhagic, infectious, or neoplastic processes; alterations in hormonal secretion or action by HIV infection5; and interference with hormonal secretion or action by antibodies, cytokines, or other . . .