A Semi-empirical Model for Radionuclide Transport in Mammals

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Abstract
Complicated exposure situations are often encountered when performing a theoretical hazards analysis. It is often required to piece together smaller models of less complicated animal experiments such that dose computations may be performed for these hypothetical exposures. Since experimentalists have encountered dissimilarities in tissue distribution when changing the modes of dose administration, this model coupling procedure was considered unwise. An attempt has been made to develop a method that would identify those mechanisms that affect these route of entry difficulties. This method was used during a system hazard analysis on a 210Po fueled thermoelectric generator. The method uncovered the possibility that physiological mechanisms in respiratory lymph node and liver metabolism have not been treated in the existing models. The method did not reveal any inconsistencies in critical organ distribution and retention. Therefore this study supported the procedure of coupling together the simpler models for calculating doses to the critical organs from 210Po.

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