Mutations in cyclic AMP-dependent protein kinase and corticotropin (ACTH)-sensitive adenylate cyclase affect adrenal steroidogenesis.
- 1 April 1979
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 76 (4) , 1896-1900
- https://doi.org/10.1073/pnas.76.4.1896
Abstract
Two groups of mutant clones were isolated from Y1 [mouse] adrenocortical tumor cells. One group, Y1(Kin), exhibited altered cytosolic cyclic[c]AMP-dependent protein kinase activity; the 2nd group, Y1(Cyc), exhibited diminished corticotropin-responsive adenylate cyclase activity. Steroidogenic responses to ACTH and cyclic nucleotides closely paralleled cAMP-dependent protein kinase activity in the Y1(Kin) mutants. In Y1(Cyc) mutants, ACTH had little effect on steroidogenesis, whereas cyclic nucleotides were fully active. Adenylate cyclase and cyclic AMP-dependent protein kinase apparently are obligatory components of the ACTH-stimulated steroidogenic pathway.This publication has 45 references indexed in Scilit:
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