Contact and Plasmin Kinin-Forming Systems in the Blood

Publisher Website
Google Scholar
Abstract
By means of preparations of two different kininogens, the existence of two kallikreins, postulated previously, that is one activated by the contact factor – contact kallikrein, and another by plasmin – plasmin kallikrein, has been confirmed. Stasis plasma or plasma from blood taken without stasis incubated at 37 ° C can be a source of contact kallikrein. It was found that modified plasma, that is plasma acidified to pH 2 and realkalized after 10 min, is suitable material for demonstrating that plasmin activates plasmin kallikrein. Plasmin kallikrein in the plasma has two substrates: kininogen – from which it releases kinins, and contact kallikrein which it inactivates. A diagram showing the activation of kinin-forming systems in the blood plasma is proposed. * This investigation was supported partially by a grant from the Committee on Physiology, Section of Medical Sciences, Polish Academy of Sciences.

This publication has 27 references indexed in Scilit: