Effect of hydroxypropyl-β-cyclodextrin on efficacy of oral itraconazole in disseminated murine cryptococcosis
- 1 September 1993
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 32 (3) , 459-463
- https://doi.org/10.1093/jac/32.3.459
Abstract
The therapeutic efficacy of itraconazole solubilized in either the commonly used vehicle, polyethylene-glycol-200 (PEG) or hydroxypropyl β-cyclodextrin was compared in a murine model of disseminated cryptococcosis. Itraconazole at doses of up to 120 mg/kg/day solubilized in PEG were found not to be effective. However, itraconazole at doses ≥ 30 mg/kg/day solubilized in hydroxypropyl-β-cyclodextrin markedly prolonged survival and a relationship between dose and survival was seen.Keywords
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