Specification and maintenance of the spinal cord stem zone
Open Access
- 1 October 2005
- journal article
- Published by The Company of Biologists in Development
- Vol. 132 (19) , 4273-4283
- https://doi.org/10.1242/dev.02009
Abstract
Epiblast cells adjacent to the regressing primitive streak behave as a stem zone that progressively generates the entire spinal cord and also contributes to paraxial mesoderm. Despite this fundamental task, this cell population is poorly characterised, and the tissue interactions and signalling pathways that specify this unique region are unknown. Fibroblast growth factor (FGF) is implicated but it is unclear whether it is sufficient and/or directly required for stem zone specification. It is also not understood how establishment of the stem zone relates to the acquisition of spinal cord identity as indicated by expression of caudal Hox genes.Keywords
This publication has 76 references indexed in Scilit:
- Retinoic acid signalling centres in the avian embryo identified by sites of expression of synthesising and catabolising enzymesDevelopmental Dynamics, 2003
- Mice Lacking Zfhx1b, the Gene That Codes for Smad-Interacting Protein-1, Reveal a Role for Multiple Neural Crest Cell Defects in the Etiology of Hirschsprung Disease–Mental Retardation SyndromeAmerican Journal of Human Genetics, 2003
- Conversion of embryonic stem cells into neuroectodermal precursors in adherent monocultureNature Biotechnology, 2003
- Comparison of the expression patterns of several fibroblast growth factors during chick gastrulation and neurulationBrain Structure and Function, 2002
- Cell Movement Patterns during Gastrulation in the Chick Are Controlled by Positive and Negative Chemotaxis Mediated by FGF4 and FGF8Developmental Cell, 2002
- Progressive induction of caudal neural character by graded Wnt signalingNature Neuroscience, 2002
- Patterning the Embryonic AxisCell, 2001
- The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structuresGenes & Development, 2001
- cash4, a novel achaete-scute homolog induced by Hensen's node during generation of the posterior nervous system.Genes & Development, 1997
- Vitamin A-deficient quail embryos have half a hindbrain and other neural defectsCurrent Biology, 1996