The Functional Pattern of the Transplanted Kidney during the First Year

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Abstract
Prospective studies on kidney function were carried out 1-14 mo. after transplantation in 2 groups of recipients of renal transplants. Both groups were characterized by immediate graft function. The 1st group had transplants from living donors, the 2nd had received cadaveric kidneys. In the 1st group a functional maximum (as measured by 125iothalamate, creatinine and 131I-hippuran clearances) was reached during the first 3 wk after transplantation, approximating 70% of the donors'' bilateral preoperative function. In the 2nd group kidney function was constant during the period of study, the values being almost identical with those observed in the 1st group. At investigation 12-14 mo. after transplantation, the 2 groups were compared with the remaining cadaveric transplants carried out during the period of study, the latter being primarily graft anuric. Graft function in the primarily anuric grafts was poorer than in those with initial function. Graft survival was poorer at 1 yr in the group characterized by primary graft anuria than in the other groups. Graft survival at 1 yr was 68% in cadaveric kidney transplants with good initial function.