The stalk region of dynamin drives the constriction of dynamin tubes
- 9 May 2004
- journal article
- Published by Springer Nature in Nature Structural & Molecular Biology
- Vol. 11 (6) , 574-575
- https://doi.org/10.1038/nsmb762
Abstract
The GTPase dynamin is essential for numerous vesiculation events including clathrin-mediated endocytosis. Upon GTP hydrolysis, dynamin constricts a lipid bilayer. Previously, a three-dimensional structure of mutant dynamin in the constricted state was determined by helical reconstruction methods. We solved the nonconstricted state by a single-particle approach and show that the stalk region of dynamin undergoes a large conformational change that drives tube constriction.Keywords
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