Mice Lacking the Nkx6.2 (Gtx) Homeodomain Transcription Factor Develop and Reproduce Normally
Open Access
- 1 July 2001
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 21 (13) , 4399-4403
- https://doi.org/10.1128/mcb.21.13.4399-4403.2001
Abstract
The Nkx homeobox genes are expressed in a variety of developing tissues and have been implicated in controlling tissue patterning and cell differentiation. Expression of Nkx6.2(Gtx) was previously observed in the embryonic neural tube, testis, and differentiating oligodendrocytes. To investigate the role of Nkx6.2 in the control of cell specification and differentiation, we generated mice with null mutations inNkx6.2 using the standard gene targeting approach. Null mutant mice were viable and fertile without apparent histological and immunohistochemical changes in the central nervous systems and testis. The absence of detectable phenotypes suggests a redundant function ofNkx6.2 in mouse development.Keywords
This publication has 17 references indexed in Scilit:
- Selective Expression of Nkx-2.2 Transcription Factor in Chicken Oligodendrocyte Progenitors and Implications for the Embryonic Origin of OligodendrocytesMolecular and Cellular Neuroscience, 2000
- The re-expression of the homeodomain transcription factor Gtx during remyelination of experimentally induced demyelinating lesions in young and old rat brainNeuroscience, 2000
- Gtx, an oligodendrocyte‐specific homeodomain protein, has repressor activityJournal of Neuroscience Research, 2000
- Expression and regulation of the chickenNkx-6.2 homeobox gene suggest its possible involvement in the ventral neural patterning and cell fate specificationDevelopmental Dynamics, 1999
- Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signallingNature, 1999
- Specification of dopaminergic and serotonergic neurons in the vertebrate CNSCurrent Opinion in Neurobiology, 1999
- Null mutation of Dlx-2 results in abnormal morphogenesis of proximal first and second branchial arch derivatives and abnormal differentiation in the forebrain.Genes & Development, 1995
- Distinct temporal expression of mouse Nkx-5.1 and Nkx-5.2 homeo☐ genes during brain and ear developmentMechanisms of Development, 1995
- Control of neuronal diversity by the floor plate: Contact-mediated induction of midbrain dopaminergic neuronsCell, 1995
- A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labelled cRNA probesHistochemistry and Cell Biology, 1993