Recognition of the pre-miRNA structure by Drosophila Dicer-1
- 18 September 2011
- journal article
- research article
- Published by Springer Nature in Nature Structural & Molecular Biology
- Vol. 18 (10) , 1153-1158
- https://doi.org/10.1038/nsmb.2125
Abstract
It has been unclear how fly Dicer-1 exclusively recognizes pre-miRNAs. New analyses show that fly Dicer-1 recognizes the single-stranded terminal loop structure of pre-miRNAs through its N-terminal helicase domain, checks the loop size and measures the distance between the 3′ overhang and the terminal loop. This unique mechanism allows fly Dicer-1 to inspect the authenticity of pre-miRNA structures.Keywords
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