Correlation of aberrant proliferation with T-cell growth factor in adult T-Cell leukemia cells
- 1 April 1983
- journal article
- research article
- Published by Wiley in Hematological Oncology
- Vol. 1 (2) , 177-185
- https://doi.org/10.1002/hon.2900010208
Abstract
Peripheral blood lymphocytes from seven patients with adult T-cell leukemia (ATL) were found to lack PHA-responsiveness. However, in most of the cases, minute but distinct proliferation could be induced and maintained by human spleen cell conditioned medium containing PHA or by a combination of PHA and conditioned medium of gibbon cell line, MLA-144 (MLA-144 CM). These results indicate that the lack of response to mitogens of ATL cells might be attributed not only to the failure of these cells to produce T-cell growth factor (TCGF) upon activation, but also to their poor responsiveness to TCGF. Furthermore, a direct proliferative response to mitogen-free MLA-144 CM was shown in two out of seven patients; these two patients experienced rapidly progressive clinical courses. This observation raises the possibility that TCGF promotes the growth of ATL cells in vivo, and is related to the clinical course of the disease.Keywords
This publication has 14 references indexed in Scilit:
- A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptorNature, 1982
- T-cell Growth Factor-Dependent Leukemic Cell Growth: Therapeutic ImplicationsPublished by Springer Nature ,1982
- Human cutaneous T cell lymphoma and leukemia cell lines produce and respond to T cell growth factorThe Journal of Experimental Medicine, 1981
- Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera.Proceedings of the National Academy of Sciences, 1981
- T-cell lines established from human T-lymphocytic neoplasias by direct response to T-cell growth factor.Proceedings of the National Academy of Sciences, 1980
- T‐Cell Growth FactorImmunological Reviews, 1980
- Discrete stages of human intrathymic differentiation: Analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineageProceedings of the National Academy of Sciences, 1980
- Suppressive activity of some leukemic T cells from adult patients in JapanClinical Immunology and Immunopathology, 1980
- T-T-cell interactions during the vitro cytotoxic allograft responses. I. Soluble products from activated Lyl+ T cells trigger autonomously antigen-primed Ly23+ T cells to cell proliferation and cytolytic activity.The Journal of Experimental Medicine, 1978
- Cutaneous T-Cell Lymphomas: The Sézary Syndrome, Mycosis Fungoides, and Related DisordersAnnals of Internal Medicine, 1975