EFFECTS OF DEXAMETHASONE ON LIPID MOBILIZATION IN THE RAT

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Abstract
The effects of acute and prolonged dexamethasone administration on adipose tissue lipid metabolism were studied, by injection of dexamethasone into rats in vivo and the investigation of adipose tissue in vitro. While increasing doses of dexamethasone (evaluated 4 hours after injection) resulted in an increase of lipolysis, chronic dexamethasone administration induced significant suppression of lipolysis together with an increase in plasma insulin. When evaluated 4 hours after injection, lipolysis increase was first observed after a dose of 3μg and became progressively more marked when higher doses were used. Re-esterification however, did not contribute to the inhibition of lipid mobilization. Prolonged dexamethasone administration induced retardation of weight gain and growth, explainable at least in part by a decrease in food intake and a decrease of muscle weight, while the weight of the liver and adipose tissue was unchanged.

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