Decreased Spinal Cord cGMP in Murine (Wobbler) Spontaneous Lower Motor Neuron Degeneration
- 1 September 1978
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 35 (9) , 590-591
- https://doi.org/10.1001/archneur.1978.00500330038007
Abstract
• Of the secondary messengers, cyclic guanosine monophosphate, but not cyclic adenosine monophosphate, was reduced by 80% in the cervical spinal cord and by 56% in the cerebellum of clinically affected homozygote "wobbler" mice compared to sex- and age-matched litter-mate clinically unaffected control mice. A neurotransmitter, gamma aminobutyric acid, and high-energy intermediates, adenosine triphosphate and phosphocreatine, were not significantly different in affected or unaffected mice.This publication has 6 references indexed in Scilit:
- Cyclic GMP: reduction of cerebellar concentrations in ‘nervous’ mutant miceBrain Research, 1975
- The Fine Structure of the Cervical Spinal Cord, Ventral Root and Brachial Nerves in the Wobbler (WR) MouseJournal of Neuropathology and Experimental Neurology, 1975
- Cyclic Guanosine Monophosphate: Elevation in Degenerating Photoreceptor Cells of the C3H Mouse RetinaScience, 1974
- ACID HYDROLASES AND OTHER ENZYMES IN SECONDARY DEMYELINATION: A QUANTITATIVE HISTOCHEMICAL STUDY IN THE WOBBLER MOUSE1Journal of Neurochemistry, 1974
- Spinal motor neurones in murine muscular dystrophy and spinal muscular atrophy: A quantitative histological studyJournal of Neurology, Neurosurgery & Psychiatry, 1972
- An hereditary motor neurone disease with progressive denervation of muscle in the mouse: the mutant 'wobbler'.Journal of Neurology, Neurosurgery & Psychiatry, 1968