Combined Intracervical PGE2 and Intra‐Amniotic PGF2α for Induction of 2nd Trimester Abortion

Publisher Website
Google Scholar
Abstract
Fourteen consecutive patients (mean gestational age 18.1 weeks, range 15-23 weeks) referred for therapeutic termination of pregnancy were induced into abortion by intra-amniotic PGF2.alpha. 40 mg followed by oxytocin stimulation. 14 other patients (mean gestational age 17.9 weeks, range 15-23 weeks) were pretreated with intracervical PGE2 1.0 mg in gel for 4 h prior to induction of abortion with intra-amniotic PGF2.alpha. 40 mg without further stimulation. The induction-abortion interval for patients treated with intra-amniotic PGF2.alpha. and oxytocin, was 19.1 .+-. 2.94 h (.+-. SE, n = 14) with a success rate of 80% after 24 h. After pretreatment with intra-cervical PGE2 1.0 mg in viscous gel, intra-aminotic PGE2.alpha. 40 mg induced abortion after 11.2 .+-. 1.12 h (.+-. SE, n = 14) with a 100% success rate after 24 h. No systemic side effects of the PGE2 pretreatment were noted. No cervical laceration was observed. The results need further confirmation, but still suggest cervical priming with intracervical PGE2 1.0 mg in gel and subsequent induction of abortion by intra-amniotic PGF2.alpha. 40 mg as an attractive principle for 2nd trimester abortion.

This publication has 13 references indexed in Scilit: