The penetration of cefoxitin into peritoneal fluid

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Abstract
Twenty-five patients undergoing elective abdominal surgery received 2 g cefoxitin iv at varying times before surgery. A pre-weighed sterile 13 mm diameter assay disc was placed on the peritoneal surface for 2 to 5 min and a simultaneous serum sample was collected. The disc was re-weighed and assayed using a Bacillus subtilis and standards on similar discs containing the same volume as that in the test disc. At the end of the operation a further serum and peritoneal sample was collected. A total of 38 peritoneal samples were analysed. Ten to 20 min after cefoxitin administration the mean serum level was 132 mg/l and the mean peritoneal fluid 110 mg/l. The serum and peritoneal fluid levels fell in parallel, the half-life being about 0·72 h. The mean serum level decreased to 8 mg/l by 2·3 h and the peritoneal fluid level decreased to 8 mg/l by 1·75 h post administration. The mean peritoneal fluid levels were 86% (S.D. 27) of the simultaneous serum levels.

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