Observations on the Mandible in Association with Defects of the Lip and Palate

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Abstract
Children with cleft lip and palate had retrognathia. Mice with spontaneous cleft lip and palate, had mandibles of normal length. This difference is of interest in view of the great similarity in sex distribution, laterality, morphology and genetics between these defects in mice and man. Cortisone-induced cleft palate (in distinction to cleft palate with micrognathia and with an apparently normal mandible) was found to be accompanied by a mandible of relatively greater than normal length. This increase was due solely to a relative increase in length of the premolar mandibular corpus.