Generation and characterization of three new monoclonal antibodies detecting the allospecificities HLA‐A2, w69, HLA‐A3 and HLA‐B13
- 1 April 1987
- journal article
- research article
- Published by Wiley in Tissue Antigens
- Vol. 29 (4) , 201-207
- https://doi.org/10.1111/j.1399-0039.1987.tb01577.x
Abstract
Immunization of balb/c mice with peripheral blood mononuclear cells of a leukemic patient possessing the antigens HLA-A2,3; B7,35 resulted in the polymorphic monoclonal antibody (moab) UL-101/68 (IgM) defining HLA-A3. Immunization of a second group of balb/c mice with the lymphoblastoid cell line BER homozygous for HLA-A2; B13 revealed two polymorphic moabs UL-39/10 (IgG3) specific for HLA-B13 and UL-39/24 (IgG2b) defining HLA-A2,w69. Immunoprecipitation and polyacrylamide gel electrophoresis with the two moabs of the IgG isotype confirmed the class I structure of the recognized antigens.This publication has 15 references indexed in Scilit:
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