THE EFFECT OF SPLANCHNIC SYMPATHECTOMY IN HYPERTENSIVE PATIENTS UPON ESTIMATED HEPATIC BLOOD FLOW IN THE UPRIGHT AS CONTRASTED WITH THE HORIZONTAL POSITION 1

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Abstract
Estimations of hepatic blood flow (EHBF) were made in hypertensive patients in the horizontal and upright positions before and after splanchnic sympathectomy. After sympathectomy reductions of EHBF in the upright posture were associated with sizeable decreases in arterial pressure and little change in calculated hepatic-portal resistance (HPR), whereas, before operation reductions in EHBF in the upright posture occurred with little change in pressure and increases in HPR. Thus, HPR in 8 splanchnicectomized hypertensive patients increased on tilting from 6.8 to only 7.2 units (which is not significant statistically), whereas in 9 unoperated hypertensive patients it increased from 7.3 to 10.1 units (which is highly significant statistically). It was concluded that the splanchnic sympathetic nervous system mediates the hepatic-portal vasoconstrictor response to the upright posture in hypertensive patients and probably also in normal subjects.

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