Role of oxidized low density lipoprotein in atherogenesis.
Open Access
- 1 December 1991
- journal article
- review article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 88 (6) , 1785-1792
- https://doi.org/10.1172/jci115499
Abstract
Evidence to support an important role of oxidative modification in mediating the atherogenicity of LDL continues to grow. New hypotheses suggest mechanisms by which Ox-LDL or products of Ox-LDL can affect many components of the atherogenic process, including vasomotor properties and thrombosis, as well as lesion initiation and progression itself. These ideas suggest new approaches, that in combination with lowering of plasma cholesterol, could lead to the prevention of atherosclerosis and its complications.Keywords
This publication has 59 references indexed in Scilit:
- Effects of native and oxidized low density lipoproteins on formation and inactivation of endothelium-derived relaxing factor.Arteriosclerosis and Thrombosis: A Journal of Vascular Biology, 1991
- Arterial Metabolism of Lipoproteins in Relation to AtherogenesisAnnals of the New York Academy of Sciences, 1990
- Lipoprotein (a). Heterogeneity and biological relevance.Journal of Clinical Investigation, 1990
- High-density lipoprotein inhibits the oxidative modification of low-density lipoproteinBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1990
- Initiation of atherosclerotic lesions in cholesterol-fed rabbits. II. Selective retention of LDL vs. selective increases in LDL permeability in susceptible sites of arteries.Arteriosclerosis: An Official Journal of the American Heart Association, Inc., 1989
- Enhanced procoagulatory activity (PCA) of human monocytes/macrophages after in vitro stimulation with chemically modified LDLAtherosclerosis, 1989
- Beyond CholesterolNew England Journal of Medicine, 1989
- Impaired muscarinic endothelium-dependent relaxation and cyclic guanosine 5'-monophosphate formation in atherosclerotic human coronary artery and rabbit aorta.Journal of Clinical Investigation, 1987
- The Pathogenesis of Atherosclerosis — An UpdateNew England Journal of Medicine, 1986
- LDL-induced cytotoxicity and its inhibition by HDL in human vascular smooth muscle and endothelial cells in cultureAtherosclerosis, 1979