Phase changes at the end of a microtubule with a GTP cap.
Open Access
- 1 September 1984
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 81 (18) , 5772-5776
- https://doi.org/10.1073/pnas.81.18.5772
Abstract
Examination of Monte Carlo kinetic simulations, based on a realistic set of microscopic rate constants that apply to the end of a microtubule with a GTP cap, suggests that the end of a microtubule alternates between 2 quasimacroscopic phases. In one phase, the microtubule end has a GTP cap that fluctuates in size; in the other phase, the GTP cap has been lost. These repeated phase changes take place at any given tubulin concentration in a wide range of concentrations. While in the 1st phase, the microtubule grows slowly; while in the 2nd phase, it shortens rapidly and may disappear completely.This publication has 7 references indexed in Scilit:
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