IFN-γ and STAT1 are required for efficient induction of CXC chemokine receptor 3 (CXCR3) on CD4+ but not CD8+ T cells
Open Access
- 15 September 2007
- journal article
- Published by American Society of Hematology in Blood
- Vol. 110 (6) , 2215-2216
- https://doi.org/10.1182/blood-2007-03-081307
Abstract
To the editor: The CXC chemokine receptor 3 (CXCR3) regulates migration and function of T cells during inflammation. Resting T cells express low levels of CXCR3 but they up-regulate CXCR3 upon activation. Several studies suggest that T helper 1 (Th1)/Th2-associated cytokines regulate levels ofKeywords
This publication has 6 references indexed in Scilit:
- IL-21 Inhibits IFN-γ Production in Developing Th1 Cells through the Repression of Eomesodermin ExpressionThe Journal of Immunology, 2006
- Impaired interleukin (IL)-4-associated generation of CCR4-expressing T cells in neonates with hereditary allergy riskClinical and Experimental Immunology, 2004
- Recent developments in the transcriptional regulation of cytolytic effector cellsNature Reviews Immunology, 2004
- Control of Effector CD8 + T Cell Function by the Transcription Factor EomesoderminScience, 2003
- Dendritic Cells Support Sequential Reprogramming of Chemoattractant Receptor Profiles During Naive to Effector T Cell DifferentiationThe Journal of Immunology, 2003
- Induction of the chemokine receptor CXCR3 on TCR-stimulated T cells: dependence on the release from persistent TCR-triggering and requirement for IFN-γ stimulationEuropean Journal of Immunology, 2002