RESTING EARLY PEAK DIASTOLIC FILLING RATE - A SENSITIVE INDEX OF MYOCARDIAL DYSFUNCTION IN PATIENTS WITH CORONARY-ARTERY DISEASE

  • 1 January 1982
    • journal article
    • research article
    • Vol. 23  (6) , 471-478
Abstract
Resting first-pass radionuclide angiocardiography (RNA) was used to derive left-ventricular (LV) peak diastolic filling rates (PFR) in normals (Group 1: n = 12) and in patients with coronary artery disease (CAD), both without (Group 2: n = 27) and with previous myocardial infarction (Group 3: n = 23). Resting peak filling rates were significantly depressed in both Group 2 (1.61 .+-. 0.36; P < 0.01) and Group 3 (1.35 .+-. 0.26; P < 0.001) patients when compared with Group 1, normals (2.14 .+-. 0.63). Even though LV systolic function of Group 2 patients was normal and comparable to that in Group 1 (EF [ejection fraction] = 0.55 .+-. 0.06 against EF = 0.55 .+-. 0.06 NS [not significant]), diastolic dysfunction [PFR < 1.61 end diastolic volume/s (EDV/s)] was present at rest in 14 of 27 (52%). Depressed PFR values were also seen in 20 of 23 Group 3 patients (87%). Resting PFR is a sensitive and easily obtainable parameter of the diastolic dysfunction associated with CAD; abnormal PFR values are seen in almost all patients with previous myocardial damage, and a significant proportion of CAD patients without any evidence of abnormal systolic function have depressed resting PFR of the LV.

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