Effect of ginseng saponins on cholesterol metabolism. I. The level and the synthesis of serum and liver cholesterol in rats treated with ginsenosides.
- 1 January 1975
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 23 (5) , 1009-1016
- https://doi.org/10.1248/cpb.23.1009
Abstract
The in vivo effect on cholesterol metabolism of ginsenoside-Rb1, -Rc, -Rd, -Re, and -Rg1 purified from Ginseng (the root of Panax ginseng C.A. MEYER) was investigated. Four hours after the intraperitoneal injection of 5 mg of each pure ginsenoside into rats, the concentrations of serum and liver cholesterol and the incorporation of 14C-acetate into serum and liver cholesterol were determined. The results indicated the enhancement of cholesterol biosynthesis by administered saponins, particularly by ginsenoside-Rb1, a predominant component of Ginseng saponins.Keywords
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