Carcinoembryonic‐like antigen in the urine of patients with carcinoma of the bladder and normal controls

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Abstract
The urine and plasma of 16 patients with carcinoma of the bladder, and 27 normal individudls were studied for the presence of carcinoembryonic antigen (CEA). An attempt was made to determine whether urine CEA‐like antigens are filtered by the kidney or shed directly by the bladder tumor itself. There were elevated levels of CEA in the plasma of patients with bladder tumors. The urine of patients with bladder carcinoma had significantly higher levels of CEA‐like antigen than the urine of normal individuals. These same bladder tumor patients did not have a positive correlation between their plasma CEA and the urine CEA‐like antigen levels. It appears from these findings that urinary carcinoembryonic‐like antigen is shed directly into the urine and not filtered by the kidneys.