Increase in a specific cytochrome P-450 isoenzyme in the liver of congenitally jaundiced Gunn rats
- 15 February 1987
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 242 (1) , 297-300
- https://doi.org/10.1042/bj2420297
Abstract
Congenitally jaundiced (jj) Gunn rats had a greater hepatic microsomal content of a cytochrome P-450 isoenzyme, P-450c, than did the non-jaundiced (Jj) rats. No differences in content of P-450b, P-450d and pregnenolone-16 alpha-carbonitrile-induced (PCN) P-450 were found between jj and Jj rats. This is the first demonstration of a constitutive increase in a specific cytochrome P-450 isoenzyme in association with a genetic defect.This publication has 27 references indexed in Scilit:
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