SODIUM DICHLOROACETATE - ITS APPLICATION TO THERAPEUTICS OF EXPERIMENTAL HYPER-LACTATEMIA

  • 1 January 1978
    • journal article
    • research article
    • Vol. 4  (1) , 5-11
Abstract
Different types of experimental hyperlactatemia and hyperpyruvicemia with or without lowering of blood pH were induced in anesthetized dogs. The initially studied experimental model was the hyperlactatemia and hyperpyruvicemia with lowering of blood pH induced by the intraduodenal administration of high doses of phenformin. I.v. perfusion of sodium dichloroacetate (150 mg/kg infused during 20 min), which acts on the enzymatic complex of pyruvate dehydrogenase, reduced the hyperlactatemia and hyperpyruvicemia with or without acidosis provoked by phenformin injected intraduodenally (30 mg/kg), by intense muscular work, by hypoxia or by continuous perfusion of adrenaline [epinephrine]. Exogenous or endogenous insulin combined with sodium dichloroacetate reduced the hyperlactatemia and hyperpyruvicemia as well as the changes in blood pH provoked by phenformin, more strongly than did sodium dichloroacetate alone. These findings have been confirmed in the conscious dog.

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