Malignant Neuroleptic Syndrome—Its Present Status in Japan and Clinical Problems

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Abstract
Data from the 14 cases of malignant neuroleptic syndrome are summarized. Almost all cases presented excitement, delusions and hallucinations, but after administration of neuroleptic medication, the clinical picture transformed suddenly and the patient became akinetic and mute, followed by development of extrapyramidal symptoms such as muscle rigidity, tremors and dysphagia, and autonomic symptoms such as excessive perspiration, hypersalivation and dysuria and finally by a rise in body temperature.

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