Metabolism of N1-Acetylspermidine and N8-Acetylspermidine in Rats

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Abstract
Metabolism of N1-acetylspermidine and N8-acetylspermidine in rat liver and kidney was studied in vivo. N1-Acetylspermidine was metabolized primarily to putrescine while N8-acetylspermidine underwent deacetylation to yield spermidine. The rate of metabolism of these 2 compounds was much greater than that of spermidine. The rate of metabolism of N8-acetylspermidine exceeded that of N1-acetylspermidine in both liver and kidney. These rapid rates of metabolism could at least in part account for the low levels of these 2 compounds found in tissues. The differences in routes of metabolism of N1-acetylspermidine and N8-acetylspermidine may indicate differences in cellular functions of the 2 compounds.