Obviously, crystallization of information concerning atherosclerosis will come only by the proper free interplay and adequate fusion of the three major approaches to the problem, epidemiologic, clinical and experimental. We are getting to our goal--but we have not reached it yet. We have a motif, the life span unbalanced luxus diet, rich in calories, fats and cholesterol. We must look into other aspects, as for example: (1) the causes for localization of lesions in particular sites, (2) the causes for intimal ulceration, (3) the influence of hemorrhage and thrombosis, (4) the influence of physical and psychic stresses. These are, as it were, decorations to beautify the motif, they must not be mistaken for the motif itself. We have come a long way along the road to the solution of the problem of atherosclerosis in the last two decades. The goal is dimly glimpsed through the haze ahead. But we are not there yet, considerable labor on the part of many, carried out in a truly scientific atmosphere still lies ahead. But the reward will more than repay the effort still to be employed.