In vitro Activity of Moxifloxacin Compared to Other Fluoroquinolones against Different Erythromycin-Resistant Phenotypes of Group A β-hemolytic Streptococcus
- 24 December 1999
- journal article
- research article
- Published by S. Karger AG in Chemotherapy
- Vol. 46 (1) , 23-27
- https://doi.org/10.1159/000007252
Abstract
The aim of the present study was to evaluate the in vitro activity of moxifloxacin (BAY 12–8039) compared to ciprofloxacin, ofloxacin and sparfloxacin against 156 group A β-hemolytic Streptococcus strains. Sixty strains were macrolide-, lincosamide- and streptogramin-B-susceptible; 16 strains exhibited a constitutive resistance phenotype; 32 strains exhibited an inducible phenotype, and 48 strains were characterized by the M-type efflux-dependent phenotype. The minimum inhibition concentrations were determined by an agar dilution method according to NCCLS-approved guidelines. Moxifloxacin showed an enhanced activity compared with the other fluoroquinolones against the different macrolide-resistant phenotypes.Keywords
This publication has 1 reference indexed in Scilit:
- Erythromycin Resistance in Group A Beta Hemolytic StreptococcusChemotherapy, 1998