Occurrence of Lipoprotein-X Associated with Intravenous Administration of Lipid Emulsion in Adults

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Abstract
The intravenous lipid emulsion, Intralipid, both in vivo and in vitro causes a false-positive lipoprotein-X (LP-X) by Immunoelectrophoresis and the electrophoresis-polyanion precipitation (EPAP) technic. The in vivo phenomenon has been shown to occur in adults, previously reported only in neonates. The false-positive LP-X may persist in the blood stream for some time following cessation of administration of the “Intralipid”. This phenomenon should be taken into consideration when interpreting results of LP-X tests by these technics. It also has been shown that the presence of apolipoprotein-C is not necessary for LP-X-like cathodal mobility and precipitation by the EPAP technic of complexes of albumin and Intralipid.