Penicillin biosynthesis: active site mapping withL-α-aminoadipoyl-(C-methyl-L-cysteinyl)-D-valine variants
- 1 January 1987
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 21,p. 1664-1667
- https://doi.org/10.1039/c39870001664
Abstract
A series of structural variants of the cysteinyl moiety of the natural precursor of penicillins, δ(L-α-aminoadipoyl)-L-cysteinyl-D-valine, have been synthesised and their effectiveness as substrates for the enzyme isopenicillin N synthetase has been evaluated.Keywords
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