Small-cell undifferentiated carcinoma of the colon

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Abstract
Colonic small-cell undifferentiated carcinoma (SCUC) is an extremely aggressive neoplasm. Five patients with colonic SCUC are described and 5 documented cases are reviewed. The longest known duration of survival is 14 mo. and all patients with follow-up of this duration died of disease. Regional lymph nodes are invariably involved at the time of diagnosis and when distant metastases were present, the liver was always affected. Of the new cases of SCUC, 4 arose in association with colonic adenomas. In 2 of these the SCUC component was confined to the superficial submucosa. Yet, both produced regional metastases and 1 had massive hepatic involvement. Ultrastructurally, colonic SCUC exhibits divergent, predominantly neuroendocrine differentiation. The ultrastructural features and association with colonic adenomas suggest an endodermal rather than neuroectodermal derivation.

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