A Chromosomal Abnormality in Acute Myeloblastic Leukemia

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Abstract
THE application of chromosome-counting technics to the study of cancer has been less spectacular in demonstrating specific abnormalities than studies on patients with congenital malformations, sex anomalies or mental retardation. Many observations have been made, however, and chromosomal abnormalities, both numerical (aneuploidy) and structural, have been described in cases of leukemia.1 2 3 4 5 6 In acute leukemia the only consistent abnormalities observed thus far are an increase in aneuploidy, noted by Sandberg et al.1 and Baikie and his associates,2 and an extra chromosome in 2 cases of acute myeloblastic leukemia, reported by Kinlough and Robson.3 In these 2 cases there was a modal . . .