Relation between the Major Histocompatibility (B) Locus and Autoimmune Thyroiditis in Obese Chickens
- 18 October 1974
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 186 (4160) , 274-275
- https://doi.org/10.1126/science.186.4160.274
Abstract
Obese strain chickens develop circulating autoantibodies to thyroglobulin and lymphocytic infiltration of their thyroids during aging. Two alleles, B 1 and B 4 , are found with high gene frequency at the major histocompatibility ( B ) locus. Greater pathology and higher antibody titers are observed in B 1 B 1 and B 1 B 4 birds than in their B 4 B 4 siblings.Keywords
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