Quantification of α2A and α2C adrenoceptors in the rat striatum and in different regions of the spinal cord
- 1 July 1997
- journal article
- research article
- Published by Wiley in Acta Physiologica Scandinavica
- Vol. 160 (4) , 407-412
- https://doi.org/10.1046/j.1365-201x.1997.00175.x
Abstract
The α2C‐adrenoceptor preferring radioligand [3H]‐MK912 was used for labelling α2A‐ and α2C‐adrenoceptors in the rat striatum, in the cervical, thoracic and lumbar parts of the spinal cord, and in the dorsal and ventral halves of the spinal cord. In addition, guanfacine was used as a tool to delineate the α2A‐ and α2C‐adrenoceptors. In the striatum the sites were 72% α2A‐ and 28% α2C‐adrenoceptors, while in all regions of the spinal cord the proportions of the sites were about 96% α2A‐ and 4% α2C‐adrenoceptors. A multi‐curve experimental design and computer analysis was used in order to enable the accurate quantification of the α2A‐ and α2C‐adrenoceptors in the striatum and spinal cord.Keywords
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