CANNABINOIDS BLOCK RELEASE OF SEROTONIN FROM PLATELETS INDUCED BY PLASMA FROM MIGRAINE PATIENTS

  • 1 January 1985
    • journal article
    • research article
    • Vol. 5  (4) , 243-246
Abstract
The effects were assessed of .DELTA.''THC (the psychoactive component of cannabis) and CBD and DMHP-CBD (the non-psychomimetic components of marijuana derivatives) on 14C labelled serotonin release from normal platelets, when incubated with patient''s plasma obtained during migraine attack. A statistically significant inhibitory effect (p > 0.005) of 14C serotonin release was found at 10-5M, 10-6M, 10-7M .DELTA.''THC concentrations. Plasma of migraine patients obtained in attack-free periods revealed no significant inhibitory effect on 14C serotonin release from normal platelets using the same .DELTA.''THC concentration. CBD and DMHP-CBD had no significant inhibitory effect on 14C serotonin release from normal platelets when tested either at migraine-free period plasma or plasma obtained during migraine attack.