Heat Stability of Hemagglutinin of Various Strains of Newcastle Disease Virus.

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Abstract
The stability of the hemagglutinin of Newcastle virus strains varies over a wide range. The hemagglutinin of one strain was destroyed by heating at 56[degree]C in a period as short as 5 min. and that of another only partly diminished after 6 hrs. of heating. Neither a limited number of successive egg transfers nor the sampling of many individual eggs gave significant variation instability of an individual strain. 24 strains obtained from widely distributed points in Europe and N. America over a 15-yr. period were tested for their heat stability in this study. Some correlation was obtained between heat stability, place of inoculation and time of isolation. Lacking a method sensitive enough to demonstrate antigenic subtypes of Newcastle virus, characterization of strains by the heat stability of their hemagglutinins may be of value as an indicator from the standpoint of epizootiology.