Oat cell carcinoma, phaeochromocytoma and carcinoid tumours—multiple apud cell neoplasia—A case report

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Abstract
A case of non-familial multiple APUD [amine precursor uptake and decarboxylation] cell neoplasia is described in which an oat cell carcinoma occurred in association with a pheochromocytoma and 2 gastric carcinoids. This is the 1st reported case in which an oat cell carcinoma has formed part of such a syndrome. The arguments for and against this being a chance association are briefly stated. Oat cell carcinomas may be derived from APUD cells. The same patient had autoimmune thyroid disease, and although this may be purely fortuitous, a speculative hypothesis is advanced suggesting that the deranged anterior pituitary trophic function seen in Hashimoto''s thyroiditis may have predisposed to multiple endocrine neoplasia in this case.