Influence of Allergy on Development of Early Tuberculous Lesions

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Abstract
A group of expts. designed to study the correlation of the early histological response to tuberculous infection with the development of allergy has been described and illustrated. In guinea pigs with massive primary infections of the peritoneal cavity or testicles, reinfectious lesions were produced on successive days and the animals simultaneously skin tested for tuberculin sensitivity. After the lapse of varying periods of time the primary and reinfectious lesions and the tuberculin reactions were compared histologically. Under the conditions employed and within the limits of error of the method, it was found that the 1st appearance of significant numbers of large mononuclear cells and the development of detectable tuberculin sensitivity occurred simultaneously between the 3d and 4th days after the primary infection. The significance of these observations in relation to the authors'' previously advanced hypothesis that bacterial allergy is responsible for the early granu-lomatous reaction of the host is discussed.

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